Adrenergic receptor response in hypothyroidism.
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Adrenergic receptor response in hypothyroidism. An in vitro study on human adipose tissue and rabbit aorta. by Urban Rosenqvist

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Published by Almqvist & Wiksell in Stockholm .
Written in English

Subjects:

  • Hypothyroidism.,
  • Adrenergic mechanisms.

Book details:

Edition Notes

Includes bibliographical references.

SeriesActa medica Scandinavica. Supplementum,, 532
Classifications
LC ClassificationsRC657 .R67
The Physical Object
Pagination28 p.
Number of Pages28
ID Numbers
Open LibraryOL5472888M
LC Control Number73176093

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Ginsberg et al. 20) demonstrated increased beta-adrenergic receptor density of mononuclear cells in T 3-induced thyrotoxicosis. Anderson 21) reported the increase of beta-adrenergic receptor number of leukocytes in hyperthyroidism. Furthermore, little has been known about the changes of beta-adrenergic receptors in by: 1.   Triiodothyronine (T 3) treatment of thyroidectomized rats increased the concentration of β-adrenergic receptors (β-AR) and decreased the density of α-adrenergic receptors (α-AR) in heart and submaxillary dectomy decreased the density of β-AR in skeletal muscle sarcolemmal membrane. These results provide evidence for the involvement of thyroid hormone in the regulation of Cited by: 1.   The widespread use of β-adrenergic receptor (βAR) antagonists (β-blockers) to treat hyperthyroidism has led to the belief that the physiological consequences of thyroid hormone (TH) excess are mediated in part via catecholamine signaling through by: Increased myocardial β-receptors and adrenergic responses in hyperthyroid pigs. Am J Physiol. ; HH Medline Google Scholar; 16 Crozatier B, Su JB, Corsin A, Bouanani NH. Species differences in myocardial β-adrenergic receptor regulation in response to hyperthyroidism. Circ Res. ; Crossref Medline Google Scholar.

  On the other hand, the vasodepressor response induced by the 5-HT is mainly mediated by 5-HT 7 (7,8,36), 5-HT 1B/1D receptors (6,37), and 5-ht 5B receptors. Remarkably, the vasodepressor response of the 5-HT reduced in hypothyroid rats at μg/kg, suggesting a dysfunction of the 5-HT vascular receptors. It can be concluded that in hypothyroidism TEG and glucose tolerance are decreased while the adrenergic response to glucose administration is enhanced. Presumably, these changes are related to decreased insulin sensitivity and responsiveness to catecholamine action. 1.   Increased catecholamine effects via increased beta–adrenergic receptor binding and post-receptor responsiveness are prominent manifestations of the hyperthyroid state (tachycardia, tremor and lid lag) and are manifested in the face of normal or lowered circulating concentrations of catecholamines (Fisher, ). Burns TW, Boyer PA, Terry BE, Langley PE, Robison GA. The effect of fasting on the adrenergic receptor activity of human adipocytes. J Lab Clin Med. Sep; 94 (3)– Rosenqvist U. Adrenergic receptor response in hypothyroidism. An in vitro study on human adipose tissue and rabbit aorta. Acta Med Scand Suppl. ; –

  adrenergic receptor: Any of several sites in the surface membranes of cells innervated by adrenergic neurons. The adrenergic receptors (or adrenoceptors) are a class of metabotropic G protein -coupled receptors that are targets of the catecholamines, especially norepinephrine or noradrenaline, and epinephrine (adrenaline). Cardiovascular alterations in hypo- and hyperthyroidism have been ascribed to changes of noradrenergic neurotransmission. In the present study the influence of thyroid hormones on adrenoceptors in the rat heart was further characterized. The effect of artificial hypothyroidism (induced by feeding 6-propylthiouracil, PTU) and hyperthyroidism (induced by daily injections of triiodothyronine. The Hyperthyroidism GUIDELINES Pocket Guide is endorsed by The American Thyroid Association and based on their latest guidelines. It contains comprehensive, graded recommendations for evaluating and treating Graves’ disease and orbitopathy, toxic adenoma, toxic multinodular goiter, destructive thyroiditis, drug-associated and other causes of thyrotoxicosis in adults, children and during. Sympathetic nervous tissue – additions catecholamine Sensitivity and I?-adrenergic receptor Numberss in bosom, skeletal musculus, adipose cells and lymph cells (1, 2, 4, 7, 8). Reduces cardiac I±-adrenergic receptors. If there is a defect in the synthesis or ordinance tracts or thyroid lead to many upsets. They are chiefly divided in two.